Sleep: slept through! Theory to the test.

Last night I took a Progesterone pill and I slept through the night on an unusual day of my cycle (day 13). I woke up refreshed and extremely happy. This supports the theory I’ve cobbled together in the last few days.

The happiness came from high serotonin and noradrenaline, I felt. And of having a good night sleep and perhaps having found another sensible theory!

On a side note:
I have noticed I’m quite excited the last few days.The amount of blog posts is indicative. This is “excited brain” on display. Not a good thing per sé.
And I feel a little sheepish that you all can see it.

I think it comes from the mB12 and Folinic Acid supplementation causing all kinds of waste to come free (akin to Copper Dumps) and raising noradrenaline. (the last week I’ve laid awake for 3 hours or more instead of the usual 1,5-2 hours). Aided by the Atlas Profilax treatment that activates overall my Sympathetic Nervous System is having a good time at the moment.
Luckily I succeed at shutting it up twice a day, when I take my horizontal rests.

The only other thing I know to do is be physically active during the day (I háve to walk outside every day since the AtlasPROfilax) and lessen the mB12 and Folinic Acid. Take a small break from Methylation.

So I’m going to the motions and I know it. I hope to calm down to my regular self in the future.

The post under this paragraph I wrote this morning for a Spanish guy on the forums that shares the same sleeping pattern as me. (should that be “as I”?)
It’s full of white space because brain fogged people need their words in small doses.

I’ve got a theory for my sleeping 5 hours and then lying wide awake for 2, being very alert. It fits all the symptoms and medical data I have.

after 5 hours I get excess noradrenaline on the brain. This prevents GABA rising and REMsleep commencing and makes one very alert.

Oral supplementing of the neurotransmitter Progesterone makes me sleep for 7 or 8 hours straight. Maybe because one of its metabolites, Allopregnanolone, dampens neurons firing and promotes GABA. It is as potent as benzo’s and sleepingpills, which is what most people use for this kind of insomnia.

Progesterone is NOT a female sex hormone.

In the brain a small amount of noradrenaline is needed after the 4,5 hours of nonREMsleep to stop the REM-off neurons from firing and let REM-on neurons start. When REM-on neurons get active GABA will rise and REMsleep will start.

REM sleep depends on high GABA.

Too much noradrenaline makes this impossible. GABA will not rise and insomnia will cause more noradrenaline. Noradrenaline is the neurotransmitter that makes you very very alert.

Reason might be MAO A not breaking down noradrenaline sufficiently due to a mutation.

Another reason might be too low Progesterone (I have this, tested and proven). Progesterone is not a female sex hormone, it is a human hormone. Testosterone is made from it. Cortisol is made from it. And it is a neurotransmitter in the brain.

In the brain Progesterone increases MAO’s activity slightly.

Progesterone’s most profound neuronal effect, however, results from its direct effect on the neuronal membrane. Progesterone has an inhibitory effect on neuronal excitation, depressing neuronal firing.

One of its metabolites in the brain is Allopregnanolone. This is a neuroactive steroid that does something with GABA. It has a potency similar to that of the most potent benzodiazepines (Valium etc) and approximately a thousand times higher than pentobarbitals (sleeping pills).

(I still need to check my sources but this one put me onto Allopregnanolone and this one researches REMsleep)

Noradrenaline is noradrenergic, meaning to do with the Sympathetic Nervous System.
Onset of REMsleep and GABA is from cholinergic brain input, it is about the Parasympathetic Nervous System. (source here)
The nervous system is not limited to the brain, of course.

– stop noradrenaline from rising (how? how? How do I get the Sympathetic Nervous System to shut up?)
– stop REM-off neurons from continious firing (how? by taking benzo’s? by taking Allopregnanolone?)
– raise GABA (how? taking precursors?)

Taking GABA is useless, it cannot go through the blood brain barrier (BBB) because it is too big a molecule, say people on the forums here. If a GABA supplement does have a soothing effect it means your BBB is leaky (search forums on this, Hip and Gestalt say smart things about this)

Progesterone: only take progesterone, no progestins. Be vigilant about this. Read the label.

Take the oral pill, not the cream, someone one the forums here said the pill form is the only form that yields Allopregnonalone. As is my own experience too.

In Europe the (only) correct brand for Progesteron is Utrogestan. It is not over the counter. Your doctor will probably resist and needs to be educated. Both on Progesterone/Progestins and on males needing this basic hormone.

A 100 mg pill gets converted to 10mg active Progestrone (the liver filters out the rest, working hard). This 10mg is the dose a regular human body needs for a regular day, it’s a physiological doses. It is what a normal body produces on its own. Supplementing the full 10mg is too much for a man who -presumably- produces at least some of his own in his adrenals. Problem.

Females need more because they also use Progestrone to balance out Estrogens. Their physiological dose varies every day and can range from 10 to 60mg. (60mg on day 21 of cycle)

Larger Utrogestan pills (200/500mg) are for females in pregnancy. They may need much more than the daily 60mg to keep their baby on board which is where the hormone gets its name: PRO-GESTational-hoRmONE and our association with it being a female sex hormone.

There is no knowing in advance how your body choses to convert the Progesterone. It may raise your Testosterone, your Cortisol, your Aldosterone. Taking too much may numb the receptors or lower your own production.
HRT is risky business. Always start low and go slow.

10 mg Progesterone is excess of what a man needs, I feel. I’d want 20 or 50mg pills to start with but these are not produced. You could cut open a capsule and take only the white liquid, I guess. It looks like paint.

One thing about taking physiological doses is that your body is able to get rid of it within the day. You are not overdosing as is often the case with conventional HRT or other drugs.

ME/CFS people probably have decreased capacity for elimination so should even take less, of any drug or supplement. On a positive note: we notice effects sooner so small doses give us information fast.

On some nights I take 100mg Utrogestan pills for my menstrual cycle and then I sleep through the night every time, unless it’s the last week before my period. I was told sleepiness was a symptom of too high a dose. Now I am not so sure. It feels awful during the day and I avoid it. But at night I sleep well and wake up with new vigour. And now I found a plausible explanation for it.

As long as my liver can stand it and I wake up feeling refreshed I am now taking Progesterone at night. The correct thing to do is find out with how low a dose I sleep through. But because my need as a female differs each day and I have CFS I’m not up for cutting up pills and taking notes yet.

For you I have no quick solution, sorry. Only this theory that, to me, makes sense and fits both our symptoms.

I just learned the antibodies to GLUTEN also block conversion from glutamate into GABA.
Leaving ones brain with too much glutamate (*boing! boing!*) and not enough GABA (zzzzz…)

source =


Having a day off from putting out the garbage.

I took the day off yesterday: I didn’t take my pills.

Did take the hydrocortison ofcourse. And vit. D. And lots of bio-identical progesteron. (I’ll be having my period any day now and my breasts were killing me. Also quite a bit of PMS symptoms so progesteron I took a lot of.  NPC creme on the breasts and Utrogestan pills orally. It helps.)

But I did not take Methyl B12 and no Folinic Acid nor Zinc.

Amazingly I felt better and better during the day and by the end of the day I caught myself singing while doing some house work. Yes, insert googly eyes here too!

At night I was so well that I made the conscious decision not to be bothered by some heavy trucks that were parked nearby, rumbling stationary throughout the night. I just turned 180 degrees in my bed so my feet were facing the noise, let out a sigh and thought of nice things:

I slept through the night!  As customary I did wake up after five hours of deep sleep but contrary to other nights I just turned on my other side and went back to sleep. No two hours of waking.

My conclusions from this day:

  1. I took one day off from detoxifying.
  2. I am detoxing on a physiological pace: one day at a time. Just like the hormones I take: no more than what the body can process in one day.
  3. underneath the detoxing I am quite healthy! I’m so glad to note how well I felt during the day. That is my baseline, my point of reference. The detox-symptoms have clouded it for months now but I feel really assured to have it resurface so soon.
  4. this MTR/MTRR detoxification uses a lot of progesteron. In the whole Methylation cycle progesteron is needed. Other people with these mutations should know this, especially women.


in other news: I have elaborated my theories on human cell biology.

I think each cell has the habit of storing garbage in the outer tips of its cell. In this fantastic little video of a white bloodcell chasing a bacterium amongst red blood cells you see how it drags along a black kind of tail behind itself. I believe this to be the cellular rubbish bin, stored in a place where it interferes the least.


link to video of white blood cell chasing and engulfing a bacteria. Yay body defense system!

When the cell divides the two daughter cells each get one tip of rubbish. This garbage gets handed down to the next generation with each cell division. It progresses down the line and builds up a little with each cell life. Eventually it’s the outer cells that inherit the most rubbish from previous generations. The cells between them inherit less rubbish from their parents.


tidbits: it takes cells 20 minutes to divide. Unless it’s a special cell, then it can take hours. Red blood cells live up to 140 days. (I am quoting from memory…)

In ‘normal humans’ each cell clears out a lot of its garbage via the Methylation Cycle.

In ‘freaky interesting humans’ with mutations in the Methylation Cycle this day-to-day rubbish isn’t getting cleared away and remains in the cells. Stored in the tips. Eventually it gets passed down to next generations as shown by my ‘interesting’ sketch above.

In the end the cell cannot divide anymore, it dies and spills all its contents in the extracellular space where other cells try and clean it up. Store it in rubbish bags of their own.

In my 30+ years me and my cells have gathered a lot of garbage. All the broccoli I ate that I couldn’t process. Any alcohol (including the ones in beauty products), any exhaust fumes, anestetic. Garlic. Cell debris from x-rays.

My cells stored so much garbage, I believe, that their overall functionality eventually got hindered. Putting my body under stress, causing system wide symptoms of illness. In my case: hormonal imbalance, stress illnesses, adrenal misfunction, malnutrition, sugar addiction etc. And lets not forget behaviour and sensitivities that remind my doctor of people with an Autistic Spectrum Disorder.

It could as easy have been a late onset auto-immune disease or diabetes, I feel. Or a ‘vague’ illness we mainly associate with women. (such as ME, CFS, Irritated Bowel Syndrome, etc).

Well. Today leisure is over, it’s back to cleaning up garbage for me.

I wonder how long it takes, how long it will be before the rubbish is cleared and I can get my mind back… Yesterday I even thought about art and design and working! But as long as there’s rubbish I cannot. I do have to amend that legal/technical document this week however, to prevent the shit-fermenting-plant they are planning to build in the field next over. That will be quite enough to keep my rubbish mind busy.
And there’s my period, today or tomorrow. I am prepared: there is food in the house, warm blankets and lots of earplugs. No visitors. I will have a blissfull two days to myself. Just drinking tea, holding my tummy and writing that paper.