Neurotransmitters: progesteron on the brain

Just for funsies I was wondering about the relation between noradrenaline (NA) and progesteron in the brain. Any neurotransmitter interference there?

Boy! Did I hit the jackpot!
It’s only from one source and I haven’t had time to check out the source itself or other sources or research but if this is true it connects a whole lot of dots.

the source: sexualhealthmedicine.com

PROGESTERON AND SEROTONINE
Progesteron and oestrogens claim serotonine receptors in the brain. Oestrogens promote the growth of these receptors, progesteron decreases it. This can account for some of the depressive feelings during PMS (post menstrual syndrome, occurring at least one week before the period, when oestrogens drop and leaves behind a field of serotonine receptors who’ve got nothing to feed upon).

PROGESTERONE AND MAO
Progesterone increases MAO activity, Estrogens decrease its functionality (!!)
Meaning Progesterone promotes excitatory neurotransmitters getting catabolized, broken down, whisked away.

People with progesterone deficiency have their brain bombarded longer by excitatory neurotransmitters? (it fits the symptoms of Estrogen excess)
How about people with progesterone deficiency AND a faulty MAO A enzyme? oooh boy….

Estrogens numbs the MAO enzyme, allowing the excitatory neurotransmitters to keep bouncing around in your head. People with natural high levels of these neurotransmitters are active, excited and happy (depending on their individual signature of the mix).
People who are low on these neurotransmitters (ADD people perhaps) get depressed when their Estrogen levels drop and Progesterone keeps egging on the break down of the few neurotransmitters they have. They would have very depressive PMS.

But it might be more complex than this. Balancing hormones teaches us that hormones are not like scales: add a little here and it will decrease over there. No, it is more complex.
Having higher levels of a transmitter makes its receptors more numb for it and makes the receptor for its antagonist more hungry. For example, taking more Progesterone enhances the level of Estrogen receptors. Making for more tender breasts during PMS, even though you are supplementing with higher levels of Progesterone than you ever had naturally.

SHORT QUESTION ABOUT HAPPINESS, ENDORPHINES
Might a happy feeling come from Endorphines and not from the mix of high dopamine and progesterone supplementation?
Progesterone correlates to feeling at ease, calm (hello PNS). Not happiness per sé.

PROGESTERONE IN THE BRAIN: SLEEP
Another article from the same source kept me awake last night:

  • Estrogenen increase the serotonergic, noradrenergic and opioidergic activity in the brain. (grrrrr!)
  • Progesterone increases MAO slightly. Progesterone’s most profound neuronal effect, however, results from its direct effect on the neuronal membrane. Progesterone has an inhibitory effect on neuronal excitation, depressing neuronal firing.
  • one of Progesterone’s metabolites is called Allopregnanolone. This is een neuroactive steroid. Allopregnanolone hyperpolarizes neurons by potentiating GABA-mediated synaptic inhibition. It acts at a neurosteroid-specific site on the GABAA receptor to facilitate chloride channel opening and prolong the inhibitory action of GABA on neurons. Allopregnanolone is one of the strongest ligands of GABAA receptors in the CNS, with a potency similar to that of the most potent benzodiazepines (Valium etc) and approximately a thousand times higher than pentobarbitals. (sleeping pills)
  • brain activity of progesterone and allopregnanolone is not dependent solely on ovarian and adrenal production. It is made in the brain itself.

TRANSLATION:

  1. Progesterone depresses neuronal firing.
  2. Its metabolite Allopregnanolone eggs on GABA activity (GABA is needed for REMsleep!)
  3. Allopregnanolone does the same as benzo’s do, the drug so many insomniacs turn to
  4. Allopregnanolone does what sleeping pills do a thousand times better
  5. Progesterone is made in the brain (what if my deficiency is expressed there too? Is it synthesized in the brain from cholesterol? How does this work?)

I
AM
GOING
TO
SCREAM
NOW

Just for a little bit.
It’s all those excited neurotransmitters you see. And not enough progesterone to depress neuronal firing.

I want more (to know about) Allopregnanolone.

 

PS a strong symptom of Progesterone overdose is sleepiness. Allopregnanolone would account for this, as it’s as potent as the strongest sleeping aids.

taking a Progesterone pill (100mg) is the one thing that gets me through the nigh and only during PMS time. Earlier in the cycle and I feel very very groggy the next morning.

PS2 on RisingPhoenix someone says that it’s oral Progesterone that gets converted to this Alloprgnanolone. Not so much the transdermal cream.

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